Prolonged release microsphere encapsulating luteinizing...

Details Prolonged release microsphere encapsulating luteinizing... Prolonged release microsphere encapsulating luteinizing...

A - Human Necessities

61

K

A61K 38/24 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/52 (2006.01) A61K 38/04 (2006.01)

Patent

CA 2358495

There is disclosed a prolonged release microsphere which can constantly release medicinal drugs, such as luteinizing hormone-releasing hormone analogues and encapsulate them at high content rates. It is prepared by dissolving a copolymer of lactide and gycolide in methylene chloride, dissolving a luteinizing hormone-releasing hormone analogue and a release- controlling material in a subsidiary solvent, combining the above two solutions with each other to produce an emulsion phase, dispersing the emulsion phase in a solution of polyvinyl alcohol in distilled water to give a single emulsion system, removing the combined solvent of the emulsion phase to generate a polymeric microsphere; freeze-drying the polymeric microsphere. The microsphere prepared has a much finer inner structure, by virtue of which the microsphere is secured in a constant release rate. The single emulsion system which simplifies the preparation, allows for the maintenance of a drug content of 10 % or more. The charged groups of the release-controlling materials associated with the polymers minimize the excess release of the oppositely charged drugs at an initial stage, playing an important role in keeping the release rate constant.

L'invention concerne une microsphère à libération prolongée, qui peut libérer constamment des substances médicinales, telles que des analogues de la lutéolibérine et qui peut en encapsuler des quantités importantes. On produit ladite microsphère en dissolvant un copolymère de lactide et de glycolide dans du chlorure de méthylène, en dissolvant un analogue de lutéolibérine et une matière de retenue dans un solvant auxiliaire, en combinant les deux solutions sus-mentionnées, de sorte qu'une phase d'émulsion soit produite, en dispersant la phase d'émulsion dans une solution de poly(alcool de vinyle) dans de l'eau distillée, afin de produire un seul système d'émulsion, en enlevant le solvant combiné de la phase d'émulsion, de manière à générer une microsphère polymère; en lyophylisant la microsphère polymère. La microsphère de l'invention présente une structure interne beaucoup plus fine et est donc sûre en ce sa vitesse de libération est constante. Le système d'émulsion unique qui simplifie la préparation, permet le maintien d'une teneur en médicament de 10 % ou plus. Les groupes chargés des matières de retenue associées aux polymères minimisent la libération excessive de médicaments à charge opposée dans une étape initiale, ce qui est important dans le maintien d'une vitesse de libération constante.

Affiliated with

Also associated with

Rating

Prolonged release microsphere encapsulating luteinizing... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prolonged release microsphere encapsulating luteinizing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prolonged release microsphere encapsulating luteinizing... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1905658