A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/56 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2410219
The invention concerns microspheres for injection delivery comprising a protein active principle and an agent coating the active principle, designed to prolong its release, free of any trace of organic solvent, and obtainable by a coating method which involves contacting under agitation the active principle with the coating agent in a supercritical fluid, said coating agent being soluble in the supercritical fluid. The protein active principle is not denatured.
La présente invention a pour objet des microsphères destinées à être administrées par voie injectable comprenant un principe actif protéique et un agent enrobant le principe actif, destiné à prolonger sa libération, dépourvues de toute trace de solvant organique, et susceptibles d'être obtenues selon un procédé d'enrobage impliquant la mise en contact sous agitation du principe actif et de l'agent enrobant dans un fluide supercritique, ledit agent enrobant étant soluble dans le fluide supercritique. Le principe actif protéique n'est pas dénaturé.
Benoit Jean-Pierre
Dulieu Claire
Richard Joel
Ethypharm
Mainelab
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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