Prolonged release of gm-csf

Details Prolonged release of gm-csf Prolonged release of gm-csf

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 9/16 (2006.01) A61K 47/30 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2491511

Formulations for controlled, prolonged release of GM-CSF have been developed. These are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof with excipients and drug loadings that yield zero order or first order release, or multiphasic release over a period of approximately three to twenty-one days, preferably one week, when administered by injection. In the preferred embodiment, the microparticles are microspheres having diameters in the range of 10 to 60 microns, formed of a blend of PLGA having different molecular weights, most preferably 6,000, 30,00 and 41,000. Other embodiments have been developed to alter the release kinetics or the manner in which the drug is distributed in vivo. For example, in some cases a polymer is selected which elicits a mild inflammatory reaction, for example, PLGA and polyanhydrides can act as chemoattractant, either due to the polymer itself or minor contaminants in the polymer, or polymers which are bioadhesive are used for transmucosal or oral delivery. In another embodiment, the GM-CSF is administered in a hydrogel which can be injected subcutaneous or at a specific site for controlled release. The microparticles or hydrogel are administered to the patient in an amount effective to stimulate proliferation of hematopoietic cells, especially white cells.

Affiliated with

Also associated with

Rating

Prolonged release of gm-csf does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prolonged release of gm-csf, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prolonged release of gm-csf will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2070051