A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/58 (2006.01) A61P 23/00 (2006.01) A61P 29/00 (2006.01) A61K 31/167 (2006.01)
Patent
CA 2705201
Methods and compositions for providing long term pain relief in, for example, surgery recovery, including injecting a composition comprising a plurality of microparticles having different sizes and at least one local anesthetic loaded into the mi-croparticles at different loading levels. Extended prolonged blockage of nerve action in sheep testing was confirmed. Some of the microparticles comprise a high loading of local anesthetic. Testing in sheep showed nerve blockage for at least six days.
L'invention concerne des procédés et des compositions pour procurer un soulagement à long terme d'une douleur, par exemple lors de la récupération après intervention chirurgicale, et comprend l'injection d'une composition comprenant une pluralité de microparticules dont les dimensions sont différentes et au moins un anesthésique local chargé dans les microparticules à différents niveaux de charge. Le blocage prolongé étendu de l'action nerveuse dans un essai sur mouton a été confirmé. Certaines microparticules comprennent une charge élevée d'anesthésique local. L'essai sur mouton a montré un blocage nerveux pendant au moins six jours.
Lynch Roland M.
Masinde Lwandiko E.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Capsulated Systems Inc.
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