Prolonged release preparation and polymers thereof

Details Prolonged release preparation and polymers thereof Prolonged release preparation and polymers thereof

C - Chemistry, Metallurgy

08

L

C08L 67/04 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 38/09 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2053468

PROLONGED RELEASE PREPARATION AND POLYMERS THEREOF Abstract of the Disclosure 1. A polymer for a prolonged release preparation which comprises (A) a polylactic acid and (B) a copolymer of glycolic acid and a hydroxycarboxylic acid of general formula Image wherein R stands for an alkyl group having 2 to 8 carbons, at a weight ratio of (A) and (B) in the range of 10/90 to 90/10. The drug is released at a constant rate from the preparation over the total release period without a large burst at the initial stage. Furthermore, the drug release period of the preparation can be freely controlled by varying the blending ratio of (A) and (B).

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