Promiscuous g-protein compositions and their use

Details Promiscuous g-protein compositions and their use Promiscuous g-protein compositions and their use

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/70 (2006.01) C12N 15/79 (2006.01) C12N 15/81 (2006.01) C12N 15/85 (2006.01) C40B 30/06 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2281898

Disclosed are compositions and methods for their use, such as in identifying G- protein coupled receptors and ligands and compounds that modulate signal transduction. The compositions and methods employ promiscuous G-proteins. Activation of the promiscuous G-protein can be detected in a variety of assays, including assays in which activation is indicated by a change in fluorescence emission of a sample that contains the composition.

La présente invention concerne des compositions et leurs procédés d'utilisation qui consistent à identifier les récepteurs couplés à la protéine G, ainsi que des ligands et des composés qui modulent la transduction du signal. Ces compositions et ces procédés font appel à des protéines G ubiquistes. Diverses analyses permettent de détecter l'activation de la protéine G ubiquiste, y compris des analyses dans lesquelles l'activation se traduit par une modification de l'émission fluorescente d'un échantillon contenant ladite composition.

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