Promiscuous pap cd4 t cell epitopes

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/16 (2006.01) A61K 35/12 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) C07K 19/00 (2006.01) C12N 15/55 (2006.01) C12N 15/62 (2006.01) C12Q 1/02 (2006.01) G01N 33/567 (2006.01) C07K 7/08 (2006.01) C07K 14/535 (2006.01) G01N 33/483 (2006.01)

Patent

CA 2660064

The present invention relates to the discovery of novel T cell epitopes of the human prostatic acid phosphatase (PAP) protein that is promiscuous for at least 15 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such an epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides.

La présente invention concerne la découverte de nouveaux épitopes de lymphocyte T de la protéine acide prostatique phosphatase (PAP) humaine qui sont ubiquistes en ce qui concerne au moins 15 allèles différents du gène HLA-DR. L'invention concerne également des compositions qui contiennent l'un des nouveaux épitopes ou un peptide de fusion d'un tel épitope et un polypeptide hétérologue. L'invention concerne de plus l'utilisation des épitopes ou de leurs peptides de fusion, et des compositions contenant les épitopes ou leurs peptides de fusion.

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