C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2536495
Promoter of synoviolin gene comprising at least a fragment of 2120th to 2130th nucleotides of the base sequence of SEQ ID NO. 1 or 2 or comprising at least a fragment of 1st to 2201st, 969th to 2201st, 1142nd to 2201st, 1699th to 2201st, 1880th to 2201st, 2002nd to 2201st, 2094th to 2201st or 2118th to 2201st nucleotides of the base sequence of SEQ ID NO. 1 or 2; and a method of regulating the transcriptive activity characterized in that the activity of this promoter is inhibited or enhanced.
L'invention concerne un promoteur du gène synoviolin comprenant au moins un fragment des nucléotides 2120 à 2130 de la séquence de bases de SEQ ID NO. 1 ou 2, ou comprenant au moins un fragment des nucléotides 1 à 2201, 969 à 2201, 1142 à 2201, 1699 à 2201, 1880 à 2201, 2002 à 2201, 2094 à 2201 ou 2118 à 2201 de la séquence de bases de SEQ ID NO. 1 ou 2. Cette invention se rapporte en outre à un procédé pour réguler l'activité transcriptionnelle, caractérisé en ce que l'activité dudit promoteur est inhibée ou renforcée.
Amano Tetsuya
Nakajima Toshihiro
Tsuchimochi Kaneyuki
Yagishita Naoko
Yamasaki Satoshi
Fetherstonhaugh & Co.
Locomogene Inc.
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