Promoter of the human fatp5 gene and uses

Details Promoter of the human fatp5 gene and uses Promoter of the human fatp5 gene and uses

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2536866

The invention relates to an isolated human nucleic acid, characterized in that it corresponds to the promoter of the human FATP5 protein, and to an isolated human nucleic acid coding for a protein, particularly for the human FATP5 protein, placed under the dependence of said promoter. The invention further relates to a vector comprising said nucleic acid, or to a host cell into which said nucleic acid or said vector has been introduced. Finally, the invention relates to the use of said nucleic acid, said vector or said host cell in a method of identifying a product capable of modulating the expression of a nucieotide sequence placed under the dependence of said promoter of the human FATP5 protein, and to said method of identification. The invention finally relates to the product capable of modulating the expression of a nucleotide sequence placed under the dependence of said promoter of the human FATP5 protein, and to the use of said product in the preparation of a drug for preventing and/or treating diabetes or for inducing the .beta. ~oxidation of fatty acids in the liver.

L'invention concerne un acide nucléique humain isolé, caractérisé en ce qu'il correspond au promoteur de la protéine humaine FATP5, ainsi qu'un acide nucléique humain isolé codant pour une protéine, notamment la protéine humaine FATP5, placé sous la dépendance dudit promoteur. L'invention concerne également un vecteur contenant ledit acide nucléique, ou bien une cellule hôte dans laquelle a été introduit ledit acide nucléique ou ledit vecteur. Enfin, l'invention concerne l'utilisation dudit acide nucléique, dudit vecteur ou de ladite cellule hôte dans une méthode d'identification d'un produit capable de moduler l'expression d'une séquence nucléotidique placée sous la dépendance dudit promoteur de la protéine humaine FATP5, et ladite méthode d'identification. L'invention concerne enfin le produit capable de moduler l'expression d'une séquence nucléotidique placée sous la dépendance dudit promoteur de la protéine humaine FATP5, et l'utilisation dudit produit dans la préparation d'un médicament destiné à prévenir et/ou à traiter le diabète ou à induire la .beta. oxydation d'acides gras dans le foie.

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