Promoter regions of the genes which code for the pilinic...

Details Promoter regions of the genes which code for the pilinic... Promoter regions of the genes which code for the pilinic...

C - Chemistry, Metallurgy

12

N

167/135, 195/1.2

C12N 15/70 (2006.01) A61K 39/10 (2006.01) C07K 14/235 (2006.01) C12N 5/10 (2006.01) C12N 15/74 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2029146

41 ABSTRACT OF THE DISCLOSURE The isolation and characterisation of the promoter regions of the genes which code for the pilinic subunits fim2, fim3 and fimx of Bordetella pertussis, are described, as well as the construction of vectors containing the regions, and microorganisms transformed by the vectors. The promoter regions, or nucleotide fragments thereof, are particularly useful for the regulable or non-regulable expression of genes which code for a protein of interest in a strain of Bordetella. The transformed Bordetella strains are particularly suitable for the development of an effective anti-pertussis vaccine.

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