Promoters exhibiting endothelial cell specificity and...

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/04 (2006.01) C12N 5/00 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2587469

Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.

L'invention concerne des séquences polynucléotidiques isolées présentant une activité de promoteur spécifique de cellules endothéliales et de nouveaux éléments cis-régulateurs, ainsi que des méthodes d'utilisation de ceux-ci permettant de traiter des maladies caractérisées par une néovascularisation aberrante ou par une croissance cellulaire aberrante.

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