Promoters exhibiting endothelial cell specificity and...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/861 (2006.01) C12N 15/113 (2010.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2685394

Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.

La présente invention concerne des séquences isolées de polynucléotides présentant une activité promotrice spécifique de cellules endothéliales, de nouveaux éléments cis régulateurs, et leurs procédés d'utilisation pour permettre le traitement de maladies caractérisées par une néovascularisation ou une croissance cellulaire aberrante.

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