C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 14/515 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01)
Patent
CA 2483996
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further disclosed is a method of expressing a nucleic acid sequence of interest in endothelial cells.
L'invention concerne un polynucléotide isolé qui agit comme un promoteur dans les cellules eucaryotes. Comme il est précisé dans l'invention, ce polynucléotide isolé comprend un activateur spécifique endothélial. L'invention concerne par ailleurs une méthode d'expression d'une séquence d'acide nucléotidique recherchée dans des cellules endothéliales.
Bloom Nira
Breitbart Eyal
Harats Dror
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Vascular Biogenics Ltd.
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