Promoters for recombinant viral expression

Details Promoters for recombinant viral expression Promoters for recombinant viral expression

C - Chemistry, Metallurgy

12

N

C12N 15/863 (2006.01) A61K 39/285 (2006.01)

Patent

CA 2741724

The invention relates to a promoter se-lected from a group of nucleic acids consisting of: (a) A nucleic acid having a nucleotide sequence as set out in SEQ ID NO: 1; (b) A nucleic acid having a nu-cleotide sequence derived from the nucleic acid set out in (a), comprising at least one nucleotide addition, deletion, substitution and/or inversion as compared to the nucleotide sequence of (a) and having essentially the same expression characteristics as the nucleic acid of (a); (c) A nucleic acid sequence having at least 70% identity with the nucleic acid of (a) and having essen-tially the same expression characteristics as the nucle-ic acid of (a); and (d) A nucleic acid capable of hy-bridizing to a nucleic acid of (a), (b) or (c) and having essentially the same expression characteristics as the nucleic acid of (a).

La présente invention concerne un promoteur choisi dans un groupe dacides nucléiques constitué de : (a) un acide nucléique ayant une séquence nucléotidique comme décrit dans SEQ ID NO: 1; (b) un acide nucléique ayant une séquence nucléotidique dérivée de lacide nucléique décrit dans (a), comprenant au moins une addition, délétion, substitution et/ou inversion de nucléotide par rapport à la séquence nucléotidique de (a) et ayant essentiellement les mêmes caractéristiques dexpression que lacide nucléique de (a); (c) une séquence dacide nucléique ayant au moins 70 % didentité avec lacide nucléique (a) et ayant essentiellement les mêmes caractéristiques dexpression que lacide nucléique de (a); et (d) un acide nucléique capable de shybrider avec un acide nucléique de (a), (b) ou (c) et ayant essentiellement les mêmes caractéristiques dexpression que lacide nucléique de (a).

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