Promoters of colony stimulating factor activity

Details Promoters of colony stimulating factor activity Promoters of colony stimulating factor activity

C - Chemistry, Metallurgy

12

P

167/139, 167/37,

C12P 21/00 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C12N 5/06 (2006.01) C12P 21/08 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2035861

2035861 9100919 PCTABS00003 The present invention relates to the identification of promoters of myelopoietic blood cell production. In particular, an agent has been discovered that enhances myelopoietic colony stimulating factor activity. The agent comprises cytokines that are also capable of binding to heparin, and inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously. Particular agents comprise the inflammatory cytokines MIP-1 and MIP-2. Diagnostic and therapeutic utilities are proposed, and pharmaceutical compositions are likewise set forth.

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