Promoters to control cell differentiation

Details Promoters to control cell differentiation Promoters to control cell differentiation

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 35/50 (2006.01) C07K 14/82 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/54 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2464417

Recombinant vectors or constructs are prepared comprising a polynucleotide that encodes a conditionally-inducible oncogene operably linked to the enhancer element of the second intron of the nestin gene, or a functional fragment thereof. The constructs can be used to produce conditionally immortal cells, for transplantation.

L'invention concerne des vecteurs ou constructions recombinant(e)s préparé(e)s, qui comprennent un polynucléotide codant un oncogène inductible sous condition lié de manière fonctionnelle à une séquence activatrice du second intron du gène de la nestine, ou un fragment fonctionnel dudit gène. Ces constructions peuvent être utilisées pour produire des cellules immortelles sous condition destinées à la greffe.

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