C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/245 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 7/08 (2006.01) C12N 15/90 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2226546
A peptide contains the amino acid sequence shown in SEQ ID No:1, or conservative amino acid substitutions thereof. The amino acids at positions 1, 2, 4, 17, 19 and 20 of SEQ ID No:1, asparagine, glutamine, arginine, threonine, glycine and glycine, respectively, are highly conserved. The peptide is capable of promoting pairing of a single-stranded DNA molecule and a double-stranded DNA molecule. The single-stranded DNA molecule is homologous to at least a portion of the double-stranded DNA molecule. The single-stranded DNA molecule and the double-stranded DNA moleculeform a three-stranded DNA molecule.
L'invention porte sur un peptide comportant la séquence d'acides aminés SEQ ID N· 1 ou ses substitutions conservatrices d'acides aminés. Les acides aminés en position 1, 2, 4, 17, 19 et 20 de la SEQ ID N· 1, respectivement l'asparagine, la glutamine, l'arginine, la thréonine, la glycine et la glycine sont éminemment conservés. Ledit peptide a la capacité de favoriser les appariements entre molécules d'ADN monobrin et double brin. La molécule d'ADN monobrin est l'homologue d'au moins une partie de la molécule d'ADN double brin, et les molécules d'ADN monobrin et double brin forment ensemble une molécule d'ADN triple brin.
Camerini-Otero R. Daniel
Kinal Hai
Voloshin Oleg
Wang Lijiang
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Fetherstonhaugh & Co.
The Government Of The United States Of America
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