Promotion of self-renewal and improved gene transduction of...

Details Promotion of self-renewal and improved gene transduction of... Promotion of self-renewal and improved gene transduction of...

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) C12N 5/0789 (2010.01) A61K 35/14 (2006.01) A61K 48/00 (2006.01) C12N 15/867 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2346152

A method of promoting stem cell self-renewal is disclosed which comprises exposing a population of stem cells, particularly hematopoietic stem cells, to an effective dose of a histone deacetylase inhibitor, particularly trichostatin A, trapoxin, or chlamydocin. The invention is also directed to the use of histone deacetylase inhibitors to increase the number of transduced stem cells.

L'invention porte sur un procédé visant à favoriser l'autorenouvellement des cellules souches et consistant à exposer une population de cellules souches, notamment les cellules souches hématopoïétiques, à une dose effective d'un inhibiteur de désacétylase de l'histone, notamment la trichostatine ou la chlamydocine. L'invention porte également sur l'utilisation des inhibiteurs de désacétylase de l'histone permettant d'accroître le nombre des cellules souches ayant subi une transduction.

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