C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2347835
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
La présente invention concerne des compositions et des procédés permettant de stimuler et d'inhiber l'angiogenèse et la vascularisation cardiaque des mammifères, y-compris des humains. Ces compositions sont à base de polypeptides, ou d'antagonistes de ces polypeptides, identifiés par rapport à l'une ou l'autre des utilisations considérées. Les troubles qu'envisagent de diagnostiquer, de prévenir ou de traiter ces compositions sont essentiellement des traumatismes tels que les blessures, divers cancers, et des troubles affectant les vaisseaux sanguins tels que l'athérosclérose et l'hypertrophie cardiaque. L'invention concerne aussi les polypeptides de l'invention ainsi que des molécules d'acide nucléique codant ces polypeptides. L'invention concerne également des vecteurs et des cellules hôte comprenant ces séquences d'acides nucléiques, des molécules de polypeptides chimériques comprenant les polypeptides de l'invention fusionnés avec des séquences de polypeptides hétérologues, des anticorps se liant aux polypeptides de l'invention, et des procédés permettant la production des polypeptides de l'invention.
Ashkenazi Avi J.
Baker Kevin P.
Ferrara Napoleone
Gerber Hanspeter
Goddard Audrey
Dennison Associates
Genentech Inc.
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