C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/207, 167/276
C07D 317/28 (2006.01) A61K 31/12 (2006.01) A61K 31/335 (2006.01) A61K 31/385 (2006.01) C07C 205/04 (2006.01) C07C 205/09 (2006.01) C07C 205/32 (2006.01) C07C 205/45 (2006.01) C07C 217/64 (2006.01) C07C 217/72 (2006.01) C07C 225/16 (2006.01) C07D 339/06 (2006.01)
Patent
CA 2037084
ABSTRACT Novel propanamines, their pharmacological properties and their application for therapeutic, in particular antidiarrhoeal, purposes. A compound which is a propanamine of general formula (I) Image (I) in which : R1 is a phenyl radical optionally mono-, di- or trisubstituted, or is a 5- or 6-membered monocyclic heteroaryl radical in which the single heteroatom is nitrogen, oxygen or sulphur, R2 is a lower alkyl radical, R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkylalkyl radical, or, together with the nitrogen atom to which they are attached, form a saturated 5- to 6-membered heterocycle comprising only one heteroatom, R5 is a 5- to 7-membered cycloalkyl radical, a phenyl radical or a 5- or 6-membered monocyclic heteroaryl radical, and W represents a group =CH-QH, or a heterocycle =C[Q-(CH2)n-Q], or a group =C=Q, in which groups Q is an oxygen or sulphur atom, n has the value 2 or 3, W being =C=Q only when R3 and R4 are not both hydrogen, and their additions salts with pharmaceutically acceptable acids. A pharmaceutical composition comprising a compound of general formula (I) with the above definitions for the treatment of diarrhoeal states.
Calvet Alain
Grouhel Agnes
Jacobelli Henri
Junien Jean-Louis
Pascaud Xavier
Jouveinal S.a.
Robic
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