Propargylethoxyamino nucleotides

Details Propargylethoxyamino nucleotides Propargylethoxyamino nucleotides

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) C07H 19/04 (2006.01) C07H 19/14 (2006.01) C07H 19/16 (2006.01) C07H 21/00 (2006.01) C09B 57/00 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2230059

Propargylethoxyamino nucleosides are disclosed having structure (I), wherein R1 and R2 are -H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is -H or -OH; W2 is -OH or a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3'- position; and W3 is -PO4, -P2O7, -P3O10, phosphate analog, or -OH. Additionally, a primer extension method is provided employing the above propargylethoxyamino nucleosides.

L'invention concerne des nucléosides propargyléthoxyamino de structure (I), où R¿1? et R¿2? sont -H, un alkyle inférieur ou un marqueur, B est une base de nucléoside 7-déazapurine, purique ou pyrimidique: W¿1? est -H ou -OH; W¿2? est -OH ou une fraction rendant le nucléoside incapable de former une liaison phosphodiester en position 3'; et W¿3? est -PO¿4?, -P¿2?O¿7?, -P¿3?O¿10?, un analogue de phosphate ou -OH. De plus, ladite invention prévoit un procédé d'allongement d'amorce utilisant les nucléosides propargyléthoxyamino ci-dessus.

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