Propenone oxime ethers, a method of preparing them, and...

Details Propenone oxime ethers, a method of preparing them, and... Propenone oxime ethers, a method of preparing them, and...

C - Chemistry, Metallurgy

07

C

167/179, 260/295

C07C 251/58 (2006.01) A61K 31/15 (2006.01) C07C 45/67 (2006.01) C07C 45/74 (2006.01) C07C 49/835 (2006.01) C07C 49/84 (2006.01) C07C 333/22 (2006.01) C07D 295/088 (2006.01) C07D 333/22 (2006.01)

Patent

CA 2004350

The invention relates to new propenone oxime ethers, a method of preparing them and pharmaceutical compositions containing them. Said new propenone oxime ethers have the formula Image (I) in which - Ar and Ar' each independently denotes a phenyl group non-substituted, mono or polysubstituted, a 9-anthryl group or a naphthyl group, a pyridyl, thienyl or furyl group ; - R1 and R2 each independently denotes hydrogen, a C1-C4 alkyl group or together with the N-atom to which they are bonded a 1-pyrrolidinyl, piperidino, morpholino or 1-piperazinyl group ; - M = H, Cl, Br or a C1-C6 alkyl group - n = 2 or 3. The invention also deals with the salts of compounds of formula (I). Said compounds have good activity in the anti platelet-clotting tests and are also antagonists of the 5HT2 receptors.

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