Propenoyl hydrazides

Details Propenoyl hydrazides Propenoyl hydrazides

C - Chemistry, Metallurgy

07

D

C07D 249/16 (2006.01)

Patent

CA 2557631

The present disclosure provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the disclosure include a peptidyl propenoyl hydrazide compositions that inhibit proteases, for example cysteine proteases, either in vivoor in vitro.

La présente invention porte sur des compositions servant à inhiber les protéases, sur des procédés permettant de synthétiser ces compositions et sur des procédés d'utilisation de ces inhibiteurs de protéases. Certains aspects de cette invention concernent des compositions à base d'hydrazide de peptidyl propénoyl qui inhibent les protéases, telles que les protéases à cystéine, soit in vivo, soit in vitro.

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