Prophylactic and therapeutic agent for cancer

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/713 (2006.01) A61K 31/704 (2006.01) A61K 31/7088 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2652328

A Ras, Raf, MEK, ERK or RSK inhibitor, namely a P-glycoprotein expression inhibitor or a BCRP expression inhibitor, can be screened by utilizing the MAPK signaling activity as an indicator. It becomes possible to provide an anti-cancer agent which is reduced in resistance acquisition, and also provide an agent for preventing the resistance against an anti-cancer agent, which can enhance the therapeutic effect of the anti-cancer agent against cancer.

Selon l'invention, on peut réaliser un criblage pour rechercher un inhibiteur de Ras, Raf, MEK, ERK ou RSK, à savoir un inhibiteur de l'expression de la P-glycoprotéine ou un inhibiteur de l'expression de la BCRP (Breast Cancer Resistance Protein ; protéine de résistance au cancer du sein), en utilisant en tant qu'indicateur l'activité de signalisation de la MAPK (Mitogen-Activated Protein Kinase ; protéine kinase activée par un mitogène). Il devient possible de proposer un agent anticancéreux tel que l'acquisition par les cellules cancéreuses de la résistance audit agent est réduite et de proposer également un agent de prévention de la résistance contre un agent anticancéreux, ce qui peut augmenter l'effet thérapeutique de l'agent anticancéreux contre le cancer.

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