Prophylactic and therapeutic uses of fgf-20 in radiation...

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 15/74 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2566507

The present invention relates to methods of stimulating stem cell proliferation and engraftment, and methods of preventing and/or treating disorders associated with radiation exposure, chemotherapy, exposure to chemical/biological warfare agents, and/or any other insults affecting rapidly proliferating tissues in a body, or one or more symptoms thereof. In particular, the present invention provides methods of stimulating stem cell proliferation and/or engraftment and methods of preventing and/or treating disorders associated with one or more insults affecting rapidly proliferating tissues in a body (e.g., radiation exposure, chemical and/or biological insults) or one or more symptoms thereof by administering to a subject a composition comprising a Fibroblast Growth Factor-20 (FGF-20) protein, or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.

L'invention concerne des procédés permettant de stimuler la prolifération et la prise de greffe de cellules souches, et des méthodes permettant de prévenir et/ou de traiter des troubles associés à une exposition à des rayonnements, à la chimiothérapie, à une exposition à des agents de conduite de guerre chimiques/biologiques et/ou à d'autres agressions quelconques affectant des tissus corporels à prolifération rapide, ou à un ou plusieurs symptôme(s) de celles-ci. L'invention concerne, en particulier, des méthodes permettant de stimuler la prolifération et la prise de greffe de cellules souches, et des méthodes permettant de prévenir et/ou de traiter des troubles associés à des agressions affectant des tissus corporels à prolifération rapide (par exemple, exposition à des rayonnements, agressions chimiques/biologiques) ou à un ou plusieurs symptôme(s) de celles-ci par administration à un sujet d'une composition comprenant une protéine de facteur de croissance fibroblaste 20 (FGF-20) ou ses fragments, ses dérivés, ses variantes, ses homologues, ses analogues ou une combinaison de ceux-ci.

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