Prophylactic or therapeutic agent for allergic ophthalmic...

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61P 27/02 (2006.01) A61P 27/16 (2006.01) A61P 37/08 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2644810

Disclosed is a pharmaceutical composition for prevention or treatment of an allergic ophthalmic disease or an allergic nasal disease, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H- 1,2,3-triazolo[4,5-c][1]benzoazepine or 2-(1- isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy- 4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine, or a pharmacologically acceptable salt thereof. The pharmaceutical composition produces little adverse side effects and has a potent prophylactic effect and a potent therapeutic effect in a late phase where the treatment-resistance against an already available eye drop may be induced. The composition can be suitably used for topical administration.

La présente invention concerne une composition pharmaceutique destinée à prévenir ou à traiter une maladie ophtalmique allergique ou une maladie nasale allergique, qui comprend de la 7,8-diméthoxy-4(5H),10-dioxo-1H- 1,2,3-triazolo[4,5-c][1]benzoazépine ou de la 2-(1- isopropoxycarbonyloxy-2-méthylpropyl)-7,8-diméthoxy- 4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazépine, ou un sel pharmacologiquement acceptable de celles-ci. Ladite composition pharmaceutique produit peu d'effets indésirables et possède un puissant effet prophylactique et un puissant effet thérapeutique dans une phase tardive, lors de laquelle une résistance thérapeutique vis-à-vis d'une goutte ophtalmique déjà disponible peut être induite. Ladite composition peut être commodément utilisée pour une administration topique.

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