Prophylactic or therapeutic agent for cerebral ischemia or...

A - Human Necessities – 61 – K

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A61K 31/4188 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) C07D 491/107 (2006.01)

Patent

CA 2642933

Disclosed is a prophylactic or therapeutic agent for cerebral ischemia injury or cerebral ischemic reperfusion injury occurring in stroke such as cerebral infarction or cerebral hemorrhage, which develops its efficacy through a mechanism different from those of conventional ones and can be administered over a long period. The prophylactic or therapeutic agent comprises 6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2- carboxamide as an active ingredient. Particularly preferably, the compound is fidarestat, which is an optically resolved form having a (2S,4S) configuration.

La présente invention concerne un agent prophylactique ou thérapeutique pour les lésions induites par l'ischémie cérébrale ou les lésions induites par l'ischémie cérébrale avec reperfusion survenant dans le cadre d'un accident vasculaire cérébral tel qu'un infarctus cérébral ou une hémorragie cérébrale. L'efficacité de cet agent est basée sur un mécanisme différent de ceux des agents conventionnels et ledit agent peut être administré sur une période prolongée. L'agent prophylactique ou thérapeutique contient le principe actif 6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2- carboxamide. Le composé particulièrement préféré est le fidarestat, qui est une forme résolue optiquement et possédant une configuration (2S,4S).

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