Prophylactic or therapeutic agent for diabetes or obesity

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/06 (2006.01) A61K 31/135 (2006.01) A61K 38/05 (2006.01) A61K 38/17 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2716780

Disclosed is a safe prophylactic or therapeutic agent for diabetes or obesity. The prophylactic or therapeutic agent for diabetes or obesity comprises, as an active ingredient, a calcium receptor activator such as .gamma.-Glu-X-Gly [wherein X represents an amino acid or an amino acid derivative], .gamma.-Glu-Val-Y [wherein Y represents an amino acid or an amino acid derivative], .gamma.-Glu-Ala, .gamma.-Glu-Gly, .gamma.-Glu-Cys, y-Glu-Met, .gamma.-Glu-Thr, .gamma.-Glu-Val, .gamma.-Glu-Om, Asp-Gly, Cys-Gly, Cys-Me, Glu-Cys, Gly-Cys, Leu-Asp, .gamma.-Glu-Met(O), .gamma.-Glu-.gamma.-Glu-Val, .gamma.-Glu-Val-NH2, .gamma.-Glu-Val-ol, .gamma.-Glu-Ser, .gamma.-Glu-Tau, .gamma.-Glu-Cys(S-Me)(O), .gamma.-Glu-Leu, .gamma.-Glu-Ile, .gamma.-Glu-t-Leu, .gamma.-Glu-Cys(S-Me), cinacalcet, a cinacalcet analogue compound and protamine.

L'invention porte sur un agent prophylactique ou thérapeutique sans danger pour le diabète ou l'obésité. L'agent prophylactique ou thérapeutique pour le diabète ou l'obésité comprend, en tant que principe actif, un activateur de récepteur de calcium tel que ?-Glu-X-Gly [où X représente un acide aminé ou un dérivé d'acide aminé], ?-Glu-Val-Y [où Y représente un acide aminé ou un dérivé d'acide aminé], ?-Glu-Ala, ?-Glu-Gly, ?-Glu-Cys, ?-Glu-Met, ?-Glu-Thr, ?-Glu-Val, ?-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, ?-Glu-Met(O), ?-Glu-?-Glu-Val, ?-Glu-Val-NH2, ?-Glu-Val-ol, ?-Glu-Ser, ?-Glu-Tau, ?-Glu-Cys(S-Me)(O), ?-Glu-Leu, ?-Glu-Ile, ?-Glu-t-Leu, ?-Glu-Cys(S-Me), le cinacalcet, un composé analogue du cinacalcet et la protamine.

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