Prophylactic or therapeutic agent for diseases attributable...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 413/04 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2294453

A prophylactic or therapeutic agent for diseases attributable to infection with helicobacters, characterized by containing (S)-1-cyclopropyl -1,4-dihydro- 7- [2-(N,N-dimethylaminomethyl) morpholino]-6-fluoro-8- methoxy-4-oxoquinoline -3-carboxylic acid or pharmaceutically acceptable salts thereof. The agent is efficaceous as a single active ingredient preparation at a low dose in administration for a short period of time, is substantially free from unfavorable side effects such as tolerance and diarrhea, has low toxicity, can safely and surely remove bacteria, and is useful for prevention and treatment of diseases attributable to infection with helicobacters, such as gastritis, gastric ulcer, duodenal ulcer, malignant lymphona, and stomach cancer.

Agent prophylactique ou thérapeutique contre des maladies attribuables à une infection par des hélicobacters, caractérisé par le fait qu'il contient acide (S)-1-cyclopropyle -1,4-dihydro-7- [2-(N,N-diméthylaminométhyl) morpholino]-6-fluoro-8- méthoxy-4-oxoquinoléine -3-carboxylique ou certains de ses sels acceptables sur le plan pharmaceutique. Cet agent est efficace sous forme de préparation contenant un seul ingrédient actif à faible dose administrée pendant une durée limitée, ne présente pratiquement aucun effet secondaire indésirable, tel que la tolérance ou la diarrhée, possède une toxicité basse, peut supprimer les bactéries de façon sûre et sans danger et est utile pour la prophylaxie et le traitement de maladies pouvant être attribuées à l'infection par des hélicobacters, telles que la gastrite, l'ulcère de l'estomac, l'ulcère du duodénum, le lymphome et le cancer de l'estomac.

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