Prophylactic or therapeutic agents for diseases associated...

A - Human Necessities – 61 – K

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A61K 31/505 (2006.01)

Patent

CA 2236078

It is an object of the present invention to provide a therapeutic agent for effectively preventing or ameliorating diseases caused by dysfunction of NOS. The present invention provides a pharmaceutical composition for preventing and/or treating diseases associated with dysfunction of NOS, comprising as an effective ingredient, a compound of the formula (I): Image wherein R1 and R2 each represents a hydrogen atom or, taken together with each other, represent a single bond, while R3 represents -CH(OH)CH(OH)CH3, -CH(OCOCH3)CH(OCOCH3)CH3, -CH3, CH2OH, or a phenyl group when R1 and R2 each represents a hydrogen atom, or -COCH(OH)CH3when R1 and R2 together represent a single bond, or a pharmaceutically acceptable salt thereof.

L'invention concerne des médicaments contenant, en tant que principe actif, des composés représentés par la formule générale (I) ainsi que leurs sels pharmaceutiquement acceptables. Ces médicaments peuvent être utilisés avec efficacité pour la prévention et le traitement de maladies provoquées par une hypofonction de l'oxyde nitrique synthase. Dans la formule (I), R<1> et R<2> représentent chacun hydrogène, ou R<1> et R<2> forment conjointement une liaison simple; et R<3> représente -CH(OH)CH(OH)CH3, CH(OCOCH3)CH(OCOCH3)CH3, -CH3, -CH2OH ou phényle lorsque R<1> et R<2> représentent hydrogène, ou R<3> représente -COCH(OH)CH3 lorsque R<1> et R<2> forment conjointement une liaison simple.

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