Prophylactic use of n-methyl-d-asparate (nmda) antagonists

Details Prophylactic use of n-methyl-d-asparate (nmda) antagonists Prophylactic use of n-methyl-d-asparate (nmda) antagonists

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/00 (2006.01) A61K 31/353 (2006.01) A61K 31/40 (2006.01) A61K 31/451 (2006.01) A61K 45/06 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2357925

This invention provides a method of inhibiting in a mammal neurological damage resulting from impairment of glucose and/or oxygen supply to the brain, which method comprises administering to the mammal prior to the impairment of glucose and/or oxygen supply to the brain an amount of an NR2B subunit selective NMDA antagonist, which amount is effective in inhibiting neurological damage. This invention also provides a method of preventing primary hyperalgesia, secondary hyperalgesia, primary allodynia, secondary allodynia, or other pain caused by central sensitization, in a mammal, which method comprises administering to the mammal, prior to affliction with said pain, an amount of an NR2B subunit selective NMDA antagonist, which amount is effective in preventing said pain.

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