Prophylaxis and treatment of infectious diseases

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 31/137 (2006.01) A61K 31/365 (2006.01) A61K 31/55 (2006.01) A61K 31/7048 (2006.01) A61K 31/724 (2006.01) A61K 38/18 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2497582

The invention relates to the use of inhibitors of acid sphingomyelinase and/or inhibitors of products of the reaction catalysed by said enzyme, for the prophylaxis and/or treatment of infectious diseases and/or diseases which are influenced by infections during the course thereof. The cited products especially include ceramide. Preferably neutralising antibodies and/or anti- depressants, especially tricyclic and/or tetracyclic anti-depressants, are used as inhibitors.

L'invention concerne l'utilisation d'inhibiteurs de la sphingomyélinase acide et/ou d'inhibiteurs de produits de la réaction catalysée par cette enzyme, dans la prophylaxie et/ou la thérapie de maladies infectieuses et/ou de maladies dont le développement est influencé par des infections. Lesdits produits se présentent notamment sous la forme de céramides. Lesdits inhibiteurs sont de préférence des anticorps et/ou des antidépresseurs neutralisants, notamment des antidépresseurs tricycliques et/ou tétracycliques.

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