Propionamide derivatives useful as androgen receptor modulators

Details Propionamide derivatives useful as androgen receptor modulators Propionamide derivatives useful as androgen receptor modulators

C - Chemistry, Metallurgy

07

C

C07C 235/24 (2006.01) A61K 31/167 (2006.01) A61K 31/277 (2006.01) A61K 31/395 (2006.01) A61P 5/26 (2006.01) A61P 15/16 (2006.01) C07C 255/58 (2006.01) C07D 213/68 (2006.01)

Patent

CA 2529464

Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g. in the treatment or prevention of male hypogonadism and age-related conditions such as andropause.

L'invention concerne des composés de formule (I) dans laquelle R1 à R4, X et A sont tels que définis dans les revendications et leurs sels pharmaceutiquement acceptables et leurs esters. Les composés de formule (I) servent de modulateurs du récepteur d'androgènes à sélection tissulaire (SARM) et sont utilisés dans la thérapie hormonale, notamment dans le traitement ou la prévention de l'hypogonadisme masculin et des pathologies liées à l'âge, notamment l'andropause.

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