Propionamidine derivatives and process for their preparation

C - Chemistry – Metallurgy – 07 – D

Patent

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260/541.1

C07D 277/48 (2006.01)

Patent

CA 1266277

ABSTRACT OF THE DISCLOSURE Novel propionamidine derivatives of the formula: Image (I) wherein X is halogen, are disclosed, as well as a process for their preparation. The process involves reacting a 3-halopropionitrile of the formula: Image (III) wherein X is as defined above, with sulfamide of the formula: Image (II) in the presence of a hydrogen halide. The compounds of formula (I) are useful intermediates in the preparation of famotidine.

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