Propofol composition containing sulfite

Details Propofol composition containing sulfite Propofol composition containing sulfite

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 31/05 (2006.01) A61K 47/04 (2006.01)

Patent

CA 2319810

Sterile pharmaceutical compositions for parenteral administration containing 2, 6-diisopropylphenol (propofol) are described for use as anesthetics. The compositions comprise an oil-in-water emulsion of propofol additionally comprising an amount of sulfite sufficient to prevent significant growth of microorganisms for at least 24 h after adventitious contamination.

L'invention concerne des compositions pharmaceutiques stériles destinées à l'administration par voie parentérale et contenant 2,6-diisopropylphénole (propofol); la description se rapporte à leur utilisation en tant qu'anesthésiques. Les compositions comprennent une émulsion H/E de propofol qui contient, en outre, une certaine quantité de sulfite suffisante pour empêcher une croissance importante de micro-organismes pendant au moins les 24 heures qui suivent une contamination accidentelle.

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