Propofol formulation with enhanced microbial characteristics

Details Propofol formulation with enhanced microbial characteristics Propofol formulation with enhanced microbial characteristics

A - Human Necessities

61

K

A61K 31/05 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2366793

Formulations of intravenous anesthetic propofol emulsions are provided which contain sufficiently low concentrations of soybean oil to produce a stable emulsion and simultaneously provide reduced nutrients, which inhibit microbial growth thereby providing protection against accidental microbial contamination during long-term IV infusions. In addition to the inhibition of microbial growth due to a reduction of nutrients, the formulation exhibits unanticipated additional microbial inhibition due to an increased availability of propofol. The low concentration of soybean oil also provides a formulation that reduces the chances of fat overload when administered over an extended period of time to chronically ill patients.

L'invention concerne des formulations d'émulsions de propofol anesthésiques intraveineuses. Présentant des teneurs en huile de soja suffisamment faibles, elles permettent de produire une émulsion stable et, simultanément, fournir des nutriments réduits, ce qui inhibe la croissance microbienne et protège contre une contamination microbienne accidentelle lors perfusions IV de longue durée. Outre l'inhibition de la croissance microbienne provoquée par une réduction des nutriments, la formulation présente une inhibition microbienne supplémentaire imprévue occasionnée par une présence accrue du propofol. La faible teneur en huile de soja donne une formulation qui permet de réduire les risques de surcharge en matières grasses lorsqu'elle administrée pendant une période prolongée à des patients malades chroniques.

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