C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61P 25/28 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2168029
Prosaposin and peptide derivatives derived therefrom will promote neurite outgrowth in vitro. A peptide consensus sequence was determined by comparing the active neurite outgrowth-inducing saposin C peptide sequence with that of various hematopoietic and neuropoietic cytokines. These cytokine-derived peptides will promote the same processes as their corresponding cytokines. In addition, prosaposin and saposin C promote increased nerve cell myelination ex vivo.
Prosaposine et ses dérivés peptidiques stimulant l'excroissance des axones in vitro. Une séquence peptidique de consensus a été déterminée par comparaison de la séquence peptidique de la saposine C inductrice des excroissances des axones actifs avec celle de différentes cytokines hématopoïétiques et neuropoïétiques. Ces peptides dérivés de la cytokine favorisent les mêmes processus que les cytokines correspondantes. De plus, la prosapopine et la saposine C favorisent l'accroissement ex vivo de la myélinisation des cellules nerveuses.
Kishimoto Yasuo
O'brien John S.
Gowling Lafleur Henderson Llp
The Regents Of The University Of California
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