Prostacyclin (pgi ) analogues

Details Prostacyclin (pgi ) analogues Prostacyclin (pgi ) analogues

C - Chemistry, Metallurgy

07

D

167/205, 260/235

C07D 209/52 (2006.01) C07D 405/08 (2006.01) C07D 409/08 (2006.01)

Patent

CA 1284642

Abstract Prostacyclin (PGI 2 ) analogues represented by the formula: Image wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, lower alkenyl, lower alkynyl, lower aralkynyl, lower alkyloxy, arythio, or cyano; R3 and R4 each is hydrogen or hydroxy-protecting group; R6 is straight or branched alkyl which may be substituted with heterocycle, straight or branched alkynyl, or cycloalkyl; the wavy line indicates R- or S-configuration, or their mixture; or a salt thereof being used as antithrombotic and antiulcer drugs.

531708

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