Prostaglandin analogs as ep4 receptor agonists

Details Prostaglandin analogs as ep4 receptor agonists Prostaglandin analogs as ep4 receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/4412 (2006.01) A61P 27/06 (2006.01) C07D 211/74 (2006.01) C07D 265/10 (2006.01) C07D 279/06 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2519938

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

La présente invention concerne des agonistes sélectifs potents du sous-type EP¿4? de récepteurs de prostaglandine E2, ainsi que leur utilisation ou une préparation de ceux-ci pour traiter un glaucome et d'autres pathologies liées à une pression intraoculaire élevée dans l'oeil d'un patient. La présente invention concerne également l'utilisation desdits composés pour assurer la médiation des processus de modelage et remodelage osseux des ostéoblastes et des ostéoclastes.

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