Prostaglandin analogues

Details Prostaglandin analogues Prostaglandin analogues

C - Chemistry, Metallurgy

07

C

260/235.01

C07C 177/00 (1980.01)

Patent

CA 1151162

ABSTRACT Prostaglanain E1 analogues of the general formula: Image IV [wherein Y represents ethylene or trans-vinylene, Z represents ethylene or trans-vinylene, R1 sepresents a hydrogen atom, an alkyl group containing from 1 to 12 carbon atoms, an aralkyl group containing from 7 to 12 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms and unsubstituted or substituted by at least one alkyl group containing from 1 to 6 carbon atoms, a phenyl group unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group, alkyl group containing from 1 to 4 carbon atoms or phenyl group, a -CmH2mCOOR5 group (wherein m represents an integer of from 1 to 12 and R5 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms), a -CnH2nOR6 group (wherein R6 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms and n represents an integer of from 2 to 12). or a Image group (wherein R7 and R8 each represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms and n is as hereinbefore defined), R2 represents a hydrogen atom or a methyl or ethyl group, R3 represents a single bond or an alkylene group containing from 1 to 4 carbon atoms, R4 represents a cycloalkyl group containing from 4 to 7 carbon atoms and unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, and the wavy line attached to the C-11 and C-15 carbon atoms represents .alpha.- or .beta.-configuration or mixtures thereof] and cyclodextrin clathrates thereof, and, when R1 represents a hydrogen atom or a group CmH2mCOOR5 in which R5 represents a hydrogen atom, non-toxic salts thereof and, when R1 represents a group Image non-toxic acid addition salts thereof, are new compounds and possess characteristic prostaglandin-like properties.

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