C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/292, 260/324
C07D 207/36 (2006.01) C07D 207/273 (2006.01) C07D 211/86 (2006.01) C07D 317/28 (2006.01) C07D 317/30 (2006.01) C07F 7/18 (2006.01)
Patent
CA 1095522
ABSTRACT OF THE DISCLOSURE A compound of formula (I): Image (I) wherein: n is 0 or 1: n is 4 to 8: A is hydrogen, and when n is 0 and R5 is methyl it may also be methyl or a group CO2B wherein B is hydrogen or CO2B represents an ester group in which the B moiety contains from 1 to 12 carbon atoms: X is CO, protected CO, CROH in which R is hydrogen or C1-4 alkyl and in which the OH moiety may be protected: R1 is hydrogen, or CO2R1 represents an ester group in which the R1 moiety contains 1 to 12 carbon atoms: R4 is hydrogen, C1-9 alkyl, C5-8 cycloalkyl, C5-8 cycloalkyl-C1-6 alkyl, phenyl, phenyl C1-6 alkyl, naphtyly, naphthyl C1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethykl, C1-6 alkyl, C1-6 alkoxy, or nitro groups: D is a group -CH2-CH(R6)-CH(R7)-C(R2)(R3)-, a group -CH2-CH(R6)-CH(R7)-CH(R8)-C(R2)(R3)-, a group -CH2-CH(R6)-CH(R7)-CH(R8)-CH(R?)-C(R2)(R3)- or a group -CH2 -C(R10)(R3)- wherein R2 is hydrogen, C1-4 alkyl or phenyl: 2 R3 is hydroxy or protected hydroxy: R6, R7, R8 and R? are hydrogen, C1-4 alkyl or phenyl: and R10 is hydrogen, C1-4 alkyl or phenyl: and R5 is hydrogen, and when m is 0 it may also be methyl: and salts thereof: have a range of pharmacological activities similar to those shown by the natural prostaglandins, but these activities tend to be rather more selective.
278738
Cassidy Frederick
Moore Richard W.
Wootton Gordon
Beecham Group Limited
Borden Ladner Gervais Llp
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