Prostaglandin analogues, process for their preparation and...

Details Prostaglandin analogues, process for their preparation and... Prostaglandin analogues, process for their preparation and...

C - Chemistry, Metallurgy

07

D

167/205, 260/235

C07D 307/935 (2006.01) C07C 405/00 (2006.01) C07D 209/52 (2006.01) C07D 307/937 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1264320

ABSTRACT PROSTAGLANDIN ANALOGUES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The present invention relates to novel isomers of PGAs, PGDs, PGEs, PGFs, 6-keto-PGE1s, 6-keto-PGF1s, PGI2s, 6,9?-nitrilo-PGl1s and 6,9?-methano-PGI2s, having a specific steric configuration, which are replaced by an alkyl (C1 to C8)-substituted cycloalkyl (C4 to C7) group in (lS,S) form, in (lS,R) form or in cis form at the 15-, 16- or 17-position of the PG skeleton, and, alkyl esters thereof, non-toxic salts thereof, non-toxic acid addition salts thereof and cyclodextrin clathrates thereof, possessing more potent PG-like pharmacological activity than other isomers.

487203

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