Prostaglandin antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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260/304.7, 260/3

C07D 409/02 (2006.01) C07D 257/04 (2006.01) C07D 337/14 (2006.01)

Patent

CA 1128048

ABSTRACT OF THE DISCLOSURE Novel 7- and 8-R-dibenzo[b,f]thiepin derivatives of the formula: Image wherein n is an integer from 0 to 4; Z is thio, sulfinyl. or sulfonyl: R is hydrogen, halogen including chloro, bromo, fluoro and iodo, amino, C1 to C4 alkyl, C1 to C4 alkanoyl, hydroxyl, C1 to C4 alkoxy, thiol, C1 to C4 alkylthio, C1 to C4 alkylsulfinyl, C1 to C4 alkyl- sulfonyl, trifluoromethyl, trifluoromethylthio, cyano, carboxy, nitro and C1 to C4 alkyl or dialkylamino: A is 5-tetrazolyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, 4-hydroxy- .DELTA.3-pyrroline-3-yl-2,5-dione or Image wherein R2 is hydroxy, lower alkoxy, N,N-diloweralkyl- aminoloweralkoxy, hydroxyloweralkoxy, carboxyloweralkoxy, amino, N-loweralkylamino, N,N-diloweralkylamino, lower- alkylsulfonylamino, carboxyloweralkylamino, carboxamido- loweralkylamino and 2-imino-3-methylthiazolidine; and the dotted line indicates either an olefinic bond or satu- ration at the 10-, 11-position; and the pharmaceutically acceptable salts thereof; the compounds are employed in the treatment and control of allergic conditions such as allergic asthma.

308068

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