A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/10 (2006.01) A61K 9/00 (2006.01) A61K 31/557 (2006.01) A61K 31/5575 (2006.01) A61K 47/14 (2006.01) A61K 47/18 (2006.01) A61K 47/36 (2006.01)
Patent
CA 2457895
The invention provides methods and compositions for treating erectile dysfunction. The methods include the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a vasoactive prostaglandin composition of a semi-solid consistency. The composition comprises a vasoactive prostaglandin, a penetration enhancer, a shear-thinning polysaccharide, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N-substituted amino)-alkanoate ester, a (N-substituted amino)-alkanol alkanoate, or a mixture of these enhancers. The lipophilic compound may be an aliphatic C1 to C8 alcohol, aliphatic C2 to C30 ester, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffersystem providing a buffered pH value for said composition in the range of about 3 to about 7.4.
L'invention concerne des procédés et compositions destinés au traitement de troubles de l'érection. Lesdits procédés consistent à placer dans la fossette naviculaire du patient une quantité d'une composition de prostaglandine vasoactive de consistance semi-solide, suffisant à provoquer une érection. Ladite composition contient une prostaglandine vasoactive, un amplificateur de pénétration, un polysaccharide de fluidification par cisaillement, un composé lypophile et un système tampon acide. L'amplificateur de pénétration est un alkyl-2-(amino N-substitué)-alcanoate ester, un (amino N-substitué)-alcanol alcanoate, ou un mélange des ces amplificateurs. Le composé lypophile peut être un alcool C¿1? à C¿8? aliphatique, un ester C¿2? à C¿30? aliphatique, un ester C¿8? à C¿30? aliphatique, ou un mélange de ceux-ci. La composition selon l'invention contient un système tampon conférant à ladite composition une valeur de pH tampon s'échelonnant de 3 à environ 7,4.
Bueyuektimkin Nadir
Bueyuektimkin Servet
Yeager James L.
Mbm Intellectual Property Law Llp
Nexmed (holdings) Incorporated
LandOfFree
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