Prostaglandin derivatives

Details Prostaglandin derivatives Prostaglandin derivatives

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) A61K 31/5575 (2006.01) A61P 25/20 (2006.01)

Patent

CA 2334355

A prostaglandin derivative represented by the formula: Image wherein X is a halogen atom, n is an integer of 1 to 5, R1 is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with C1-4 alkyl group(s), a C4-13 cycloalkylalkyl group, a C5-10 alkyl group, a C5-10 alkenyl group, a C5-10 alkynyl group or a bridged cyclic hydrocarbon group, and R2 is a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl group, or a pharmaceutically acceptable salt thereof.

L'invention concerne un dérivé de prostaglandine représenté par la formule (I): dans laquelle X représente un atome d'halogène, n est un nombre entier compris entre 1 et 5, R<1> représente un groupe cycloalkyle C3-10, un groupe cycloalkyle C3-10 substitué par un groupe alkyle C1-4, un groupe cycloalkylalkyle C4-13, un groupe alkyle C5-10, un groupe alcényle C5-10, un groupe alcynyle C5-10 ou un groupe hydrocarbure cyclique ponté, et R<2> représente un atome d'hydrogène, un groupe alkyle C1-10 ou un cycloalkyle C3-10, ou un sel pharmaceutiquement acceptable de ces derniers.

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