Prostaglandin derivatives

Details Prostaglandin derivatives Prostaglandin derivatives

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) A61K 31/5575 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01) A61P 25/20 (2006.01)

Patent

CA 2382265

Prostaglandin derivatives represented by general formula (I), pharmaceutically acceptable salts thereof, or hydrates of both wherein X is halogeno; R1 is hydrogen, C1-10 alkyl, or C3-10 cycloalkyl; m is an integer of 0 to 5; and Y is a group represented by formula (a) (wherein n is an integer of 1 to 8) or a group represented by general formula (b) (wherein R2 is C3-10 cycloalkyl, C3- 10 cycloalkyl substituted with C1-4 alkyl, C1-4 alkyl substituted with C3-10 cycloalkyl, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, or a bridged cyclic hydrocarbon group).

L'invention concerne des dérivés de prostaglandine représentés par la formule générale (I), des sels pharmaceutiquement acceptables desdit dérivés, ou des hydrates desdits composés. Dans cette formule, X est halogéno, R?1¿ est hydrogène, alkyle C¿1-10? ou cycloalkyle C¿3-10?, m est un nombre entier valant entre 0 et 5, et Y est un groupe représenté par la formule (a), dans laquelle n est un nombre entier valant entre 1 et 8, ou un groupe représenté par la formule générale (b), dans laquelle R?2¿ est cycloalkyle C¿3-10?, cycloalkyle C¿3-10? substitué par alkyle C¿1-4?, alkyle C¿1-4? substitué par cycloalkyle C¿3-10?, alkyle C¿1-10?, alcényle C¿2-10?, alkylnyle C¿2-10? ou un groupe hydrocarbure cyclique ponté.

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