Prostaglandin derivatives

Details Prostaglandin derivatives Prostaglandin derivatives

C - Chemistry, Metallurgy

07

D

260/235.01, 260/

C07D 307/32 (2006.01) C07C 405/00 (2006.01) C07D 307/33 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1091664

Abstract of The Disclosure Prostaglandin type compounds of the formula Image where X is CH2-CH2, CH=CH is or C?C; Y is CH2 or 0; Q is 0 or (CH3)2C; Z is H, OH, CH3 or CH2OH and R is a linear, branched or cyclo alkyl chain of 3 to 7 carbon atoms, are prepared by essen- tially a one-step reaction from a new intermediate of the formula Image where R represents a linear, branched or cyclo alkyl group of 3 to 7 carbon atoms; Q is O or (CH3)2C; P is a removable protective group; Z is H, OP,CH3 or CH2OP and R' is H. The intermediate is useful in making known and new PGEs useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.

269070

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