Prostaglandin derivatives

Details Prostaglandin derivatives Prostaglandin derivatives

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) A61K 9/127 (2006.01) A61K 31/557 (2006.01) A61K 31/715 (2006.01) A61K 47/48 (2006.01) C08B 37/00 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2183486

Prostaglandin E1 ester derivatives of the formula (I): (see formula I) wherein R is (i) -CH2CH2-O-CO-R1, or (ii) -CH2CH2-O-CO-CH2-O-R2, and R1 and R2 each independently is C10-20 alkyl; and cyclodextrin clathrates thereof, liposome formulations containing them, processes for their preparation and pharmaceutical compositions containing them as active ingredient. The compounds of formula (I) have the effect of increasing blood flow and are useful for the prevention and/or treatment of peripheral circulatory disordar, decubitus, or skin ulcers, or for the maintenance of blood flow.

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