Prostaglandin derivatives

Details Prostaglandin derivatives Prostaglandin derivatives

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) A61K 31/5575 (2006.01) A61P 9/08 (2006.01) A61P 43/00 (2006.01) C07D 295/22 (2006.01)

Patent

CA 2384715

Novel prostaglandin derivatives represented by general formula (I), pharmaceutically acceptable salts thereof, or hydrates of both, wherein X is CH2, O, S, or the like; Y is ethylene, vinylene, ethynylene, or the like; Z is ethylene, vinylene, or ethynylene; R1 is hydrogen, alkyl, or cycloalkyl; R2 is alkyl, alkenyl, alkynyl, cycloalkyl, or the like; and R3 is hydrogen, alkyl, or the like. The prostaglandin derivatives exhibit an excellent inhibitory activity against the proliferation of vascular smooth muscle and are useful as preventive or therapeutic drugs for post-PTCA restenosis and so on.

L'invention concerne de nouveaux dérivés de prostaglandine, représentés par la formule générale (I), leurs sels acceptables sur le plan pharmaceutique, ou des hydrates desdits nouveaux dérivés ou de leurs sels. Dans cette formule, X représente CH¿2?, O, S, ou analogue; Y représente un éthylène, vinylène, éthynylène, ou analogue; R?1¿ représente un hydrogène, alkyle, ou cycloalkyle ; R?2¿ représente un alkyle, alcényle, alkynyle, cycloalkyle, ou analogue; et R?3¿ représente un hydrogène, alkyle ou analogue. Les dérivés de prostaglandine présentent une excellente activité inhibitrice contre la prolifération de muscle lisse vasculaire et sont utiles en tant que médicaments préventifs ou thérapeutiques de la resténose post-ACTP.

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