Prostaglandin derivatives and process of preparing the same

Details Prostaglandin derivatives and process of preparing the same Prostaglandin derivatives and process of preparing the same

C - Chemistry, Metallurgy

07

D

260/324

C07D 207/26 (2006.01) C07C 53/128 (2006.01) C07F 9/40 (2006.01)

Patent

CA 1074804

ABSTRACT OF THE DISCLOSURE: Prostaglandin derivatives corresponding to the general formula : Image wherein R1 represents hydrogen, methyl or ethyl, R2, R3 and R4, which are the same or different, each represent hydrogen or methyl and R is selected from.the groups consisting of : Image and Image in which R5 represents hydrogen, methyl or ethyl, R6 represents methyl, ethyl or acetyl and R7 and R8, when they are different, each repxesent hydrogen or a branched- or straight-chain alkyl group having from 1 to 7 carbon atoms or R7 and R8, when they are identical, each represent hydrogen or a straight-chain alkyl group having from 1 to 3 carbon atoms with the provises that : - when R2,R3,R4, R7 and R8 all represent hydrogen R5 is methyl or ethyl, - when R2, R3, R4, R7 and R8 all represent hydrogen and R5 then R1 is ethyl. These prostaglandin derivatives are in the form of a mixture of isomers or of an individual isomer. They are useful in the treatment of pathological states which affect the respiratory system.

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